share this page

Sandra Lenihan

Sandra Lenihan, PhD, AIChemE
Lecturer
Room: E10
Tel: +353-21-4335886
Email: Sandra.lenihan@cit.ie

Sandra graduated with a degree in Industrial Chemistry from UL in 1997 while accumulating industrial experience in Eli Lilly and Astellas.  In 2003, she completed a PhD in Physical Chemistry in UL, on the Oxidation of Ammonia (Environmental Engineering).  Upon completion of her PhD, Sandra worked as a Research Engineer with AMT Ireland, UCC and also in the Industrial Liaison Office, UCC.  In 2005, she joined Gilead Sciences (formerly ALTANA Pharma) as a Technical Support Scientist. She was responsible for the transfer of new solid dosage products from sites in Germany and USA to the facility in Cork. She also held a lead role in co-ordination of R&D activities for this company.

In 2009, Sandra was appointed as a lecturer in the Chemical and Biopharmaceutical Engineering Department.   She lectures the following modules: Biopharmaceutical Processing, Process Engineering, Biopharmaceutical Engineering, Pharmaceutical Applications and Product Design.  She supervises Final Research and Design Project and is the placement co-ordinator for Chemical Engineering students. Recently she has been proactive in securing Springboard Funding for CIT in the area of Bioprocessing and liaises regularly with NIBRT and Cork Training Centre. 

Sandra has been involved recently with a project funded by the Teaching and Learning Forum entitled:  Irish Engineering Graduates Advancing Global Manufacturing Competitiveness: Design Simulation.  This compliments her interest in modelling unit operations such as Mixing, Bioreactor and Filtration (predominantly using Dynochem). 

She has been involved with the Pharmaceutical Manufacturing Technology Centre (hosted in University of Limerick) since its inception since 2012. The Pharmaceutical Manufacturing Technology Centre (PMTC) is an Enterprise Ireland/IDA funded research group to assist the Irish Pharmaceutical Industry improve its competitiveness with core funding of €1M per annum.  She has been a principal investigator on three significant research projects to date and is also a Member of the PMTC Steering Committee since 2016. 

Current Research

Sandra and Dr Keith Byran (Mechanical Engineering) were recently funded by the Pharmaceutical Manufacturing Technology Centre (hosted in University of Limerick) for Phase 2 “Powder Modelling for Tablet Processing” (Sept  2017- Sept 2019) (Postdoc and Research Fellow). 


Previous Research

2016-2014

Sandra and Dr Keith Byran were funded (130,000 Euros) under the Enterprise Ireland Pharmaceutical Manufacturing Technology Centre for Phase 1 “Powder Modelling for Tablet Processing”.

Peer-review journal papers

A. Baroutaji, K. Bryan, S. Lenihan, ”Combination of Finite Element Method (FEM) and Drucker-Prager material model for simulation of pharmaceutical tabletting process”, accepted Materials Science and Engineering Technology, April 2017.

Book Chapter

A. Baroutaji, K. Bryan, M.Sajjia, S. Lenihan,” Mechanics and Computational Modelling of Pharmaceutical Tabletting Process”, Accepted for publication in Reference Module in Materials Science and Materials Engineering, Elsevier, 2017.

Conference papers

A. Baroutaji, K. Bryan & S. Lenihan, “Finite element modelling of pharmaceutical tablet compaction: An overview”, 32nd International Manufacturing Conference (IMC32), Belfast, September 2015.
A. Baroutaji, K. Bryan & S. Lenihan, “Numerical Simulation of Pharmaceutical Powder Compaction using ANSYS”, ANSYS Conference & 2nd CADFEM Ireland Users’ Meeting, Dublin, September 2015.
A. Baroutaji, K. Bryan, S. Lenihan, “Determination of density-dependant Drucker-Prager parameters using experimental calibration procedure”, 33nd International Manufacturing Conference (IMC33), Limerick, Ireland, September 2016
A. Baroutaji, K. Bryan, S. Lenihan, “Calibration of a density-dependant Drucker-Prager material model for modelling the die-compaction of pharmaceutical powder”, ACEX-2016, Split, Croatia, July 2016.

Poster

A. Baroutaji, K. Bryan, S. Lenihan, 2017 “Modelling the die-compaction of pharmaceutical powder“ SIMULIA Academic Users“ Science in the Age of Experience™ Global User Conference” May, 2017,  Chicago, USA.

2014-2012

Sandra and Dr Caroline O’Sullivan were funded (78,000 Euros) under the Enterprise Ireland Pharmaceutical Manufacturing Technology Centre Initial Research Programme, “Enabling and Control of Continuous Processing”. The Project established best practice through Quality by Design (QbD) and Process Analytical Technology (PAT) initiatives while achieving a quality product consistently from a continuous dry granulation process in order to support manufacturing.  Led by the School of Pharmacy in UCC, project partners include CIT’s Centre for Advanced Photonic and Process Analysis (CAPPA), and WIT’s Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC).  University of Limerick were also joint stakeholders in this project.

Paper

McAuliffe, Michael; O'Mahony, Graham; Blackshields, Caroline; Collins, John; Egan, David; Kiernan, Luke; O'Neill, Eamonn; Lenihan, Sandra; Walker, Gavin; Crean, Abina:  "The Use of PAT and Off-line Methods for Monitoring of Roller Compacted Ribbon and Granule Properties with a View to Continuous Processing”. Organic Process Research and Development; American Chemical Society,  April 2014

Conference Proceedings

A study of the effects of roller compaction, parameter on ribbon and granule properties by offline and in line methods with a view to continuous processing.  McAuliffe, Michael; O'Mahony, Graham; Blackshields, Caroline; Collins, John; Egan, David; Kiernan, Luke; O'Neill, Eamonn; Lenihan, Sandra; Walker, Gavin; Crean, Abina. Presented at the EuPAT Conference, Tailoring QbD & PAT Science to Pharmaceutical Industry Needs, HF Hotel Ipanema Park, Porto 23-24 Sept 2013.

2008-2006 Formulation

“Development of Taste Masking Technologies” collaboration with The School of Pharmacy, University College Cork and ALTANA Pharma.  Enterprise Ireland and ALTANA Pharma 500,000E- Grant funding of approximately 50%.  This collaboration consisted of two sub-projects namely Taste Evaluation of Pharmaceuticals and Taste Masking Development (formulation based project). The former project was to study the feasibility of using an electronic tongue for taste evaluation of pharmaceuticals and the latter to develop an alternative taste masking technology (two approaches used were microemulsions and solid dispersion) for oral dosage forms. Five full time researchers were employed on this project.

2003-2004 Lean Manufacturing

Food Factory of the Future - Application of lean manufacturing over a variety of Irish industries (e.g. Wyeth Medica, Sensormatic, Musgraves & Lufthansa).

1996-2003 Environmental Engineering

Supported Heteropoly Acids as Solid Acids in the Beckmann Rearrangement and Catalytic Oxidation of Ammonia to Nitrogen and Water. The former topic is a proactive approach whereas the latter project is an end of pipe solution but both resolve serious environmental problems through heterogeneous catalysis. To undertake the Catalytic Oxidation of Ammonia to Nitrogen and Water research, a micro reactor to treat effluent streams was designed.

This page was last updated 10 Aug 2017